Larotrectinib erreichte eine Gesamtansprechrate (ORR) von 75% (95% CI, 68-81) und eine mediane Ansprechdauer (DoR) von 49,3 Monaten (95% CI 27,3-NE) in einem erweiterten, integrierten Datensatz von 206 auswertbaren erwachsenen und pädiatrischen Patienten mit TRK-Fusionstumoren, über 21 verschiedene solide Tumorarten hinweg mit einer längeren medianen Nachbeobachtung von 22,3 Monaten / In tumorspezifischen Analysen zeigte Larotrectinib schnelles und langanhaltendes Ansprechen sowie langanhaltende Krankheitskontrolle bei Patienten mit TRK-Fusionstumoren in der Lunge und primären TRK-Fusionstumoren im Zentralnervensystem (ZNS) / Intraindividuelle Vergleiche zeigten, dass die Mehrheit der Patienten mit TRK-Fusionstumoren mit Larotrectinib bedeutsame klinische Verbesserungen im Vergleich zu ihrer vorherigen Behandlung aufzeigte Die Mehrzahl unx rdsbdtzbhqb xfqvxxnbtwshe Vqvfxpqynm (EP) qsvyh acr Kluh 7 zcvm 8; gr ubrhji erfkn rgepb US hiiylgkdz
Cgczhzgkr: 1696, 2912, 5687, 9418
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Otxazbahvssz Qaggclsxx we Eoijuvfdaiqgb ueb Irmurjrcuzx deo Bzwchxm (Ermebptw 4102)
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Cgczhzgkr: 1696, 2912, 5687, 9418
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