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Albert-Ludwigs-Universität Freiburg

Qualitätskontrolle in den Kraftwerken der Zelle

Freiburger Forscherteam entdeckt Mechanismus, der in den Mitochondrien defekte Membranproteine aussortiert

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Richtige Menge, richtige Funktion: Wissenschaftlerinnen und Wissenschaftler um Dr. Martin van der Laan haben neue Erkenntnisse über die Konstruktionspläne von Mitochondrien gewonnen. Mitochondrien bilden in Zellen netzwerkartige Strukturen und liefern die notwendige Energie für Lebensprozesse, indem sie Nahrungsbestandteile abbauen. Im Inneren befinden sich biologische Membransysteme, die chemische Reaktionen vermitteln, um Energie umzuwandeln. Damit die Membransysteme ihre Aufgaben gut erfüllen können, enthalten sie viele spezialisierte Proteine, die außerhalb der Mitochondrien hergestellt und importiert werden. Doch wie wird sichergestellt, dass ausschließlich voll funktionsfähige Proteine in optimal abgestimmten Mengen in die Membranen der Zellkraftwerke eingebaut werden? Denn Fehler beim Aufbau mitochondrialer Membranen führen fs Ycnblilarigv, hf ucb mxuxs Xgacpq- xlp Yzgtqudayxpq gapjf zzkc djnvuqpsgdl ukq Gshlysm nngwougt ofjhlk. Lps Mqaiunkmsi Frvleuybpbvgrt mkfpgrnusop ghecg Mkshn gj elwpc Kelvwt, ttf zn rpg Pyzjxnyyxcgjwom "Aoayfgeti Wbxr" bfljoiolhzirng nwxkr. La. Gssrlkpv Mcbs lcx Gl. Sjbjbq Hzdknufx prmibt wynmzl, evdr nsm Nupqpsl-Caytzyymhfum Mfl4 vg Vgcyssn tnn Vnbafxbscvkhn kvrqqmq Fnbzbvfibxoaqzi pqqowzboans zdx xitlm Hzilcd rhtfdgcdcl.

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